You might have run into situations in the past where you’re looking for some specific text or binary sequence, but that content is encoded with Base-64. Base-64 is an incredibly common encoding format in malware, and all kinds of binary obfuscation tools alike.
The basic idea behind Base-64 is that it takes arbitrary binary data and encodes it into 64 (naturally) ASCII characters that can be transmitted safely over any normal transmission channel. Wikipedia goes into the full details here: https://en.wikipedia.org/wiki/Base64.

